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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1991-2-1
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pubmed:abstractText |
From 1978 until 1988, 63 consecutive patients with squamous cell carcinoma of the nasal vestibule were treated by radiation therapy. Mean follow-up time was 46 months. Thirty-five patients were classified as having T1N0 tumors, 24 as T2N0; four patients were staged as T1/2N+. Treatment of the primary consisted of external radiation (n = 17), interstitial radiation (n = 37), or external radiation combined with interstitial radiation (n = 9). With respect to the N0 patients, local relapse was found in 3% (1/35) of T1 tumors and in 21% (5/24) of T2 tumors. Three out of six failures were salvaged by surgery. Elective irradiation of both sides of the neck (40 Gy) was performed in 9 T1 and in 16 T2 patients. Two regional failures occurred in the electively irradiated necks, two in the non-irradiated necks. Regarding the T1/2N+ patients, three relapsed locally and/or regionally, and one remains NED. For all 63 patients, a 5-year corrected survival of 90%, a relapse-free survival of 80%, and an overall survival of 65% were observed. In summary, for optimal local control and cosmesis we feel that for T1,2 N0 tumor stages a dose of 60 Gy for T1 and 70 Gy for T2 tumors is adequate treatment. The primary tumor is irradiated preferentially in our view, by means of interstitial techniques; furthermore, our data do not support the use of elective neck RT. Although patients rarely present with lymph node metastasis (6%), the prognosis of T1,2 N+ patients remains grim and more aggressive (surgical) treatment might be needed for this category.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0360-3016
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1363-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2262359-Adult,
pubmed-meshheading:2262359-Aged,
pubmed-meshheading:2262359-Aged, 80 and over,
pubmed-meshheading:2262359-Brachytherapy,
pubmed-meshheading:2262359-Carcinoma, Squamous Cell,
pubmed-meshheading:2262359-Female,
pubmed-meshheading:2262359-Humans,
pubmed-meshheading:2262359-Male,
pubmed-meshheading:2262359-Middle Aged,
pubmed-meshheading:2262359-Nasal Cavity,
pubmed-meshheading:2262359-Neoplasm Recurrence, Local,
pubmed-meshheading:2262359-Nose Neoplasms,
pubmed-meshheading:2262359-Radiotherapy Dosage,
pubmed-meshheading:2262359-Survival Rate
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pubmed:year |
1990
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pubmed:articleTitle |
Radiation therapy of squamous cell carcinoma of the nasal vestibule.
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pubmed:affiliation |
Department of Radiation-Oncology, Dr. Daniel den Hoed Cancer Center, University Hospital Dijkzigt, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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