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pubmed-article:2262061pubmed:abstractTextActivated T cells can be identified immunohistochemically in the intestinal lamina propria in a number of gastrointestinal diseases including food sensitive enteropathy (coeliac disease) and intractable diarrhoea of infancy. Experimental studies have shown that T cell activation in human intestinal lamina propria in vitro produces an increase in crypt cell proliferation, villous atrophy, increased HLA-DR expression on enterocytes, increased intraepithelial lymphocyte numbers, and, phenotypically, macrophage activation. All of these features are seen in food sensitive enteropathy and it is proposed that lamina propria T cell activation to food antigens plays the primary role in the pathogenesis of these disorders by altering mucosal morphology and the rate of epithelial cell proliferation.lld:pubmed
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pubmed-article:2262061pubmed:articleTitleThe role of activated T cells in transformed intestinal mucosa.lld:pubmed
pubmed-article:2262061pubmed:affiliationDepartment of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK.lld:pubmed
pubmed-article:2262061pubmed:publicationTypeJournal Articlelld:pubmed
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