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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1991-2-7
|
| pubmed:abstractText |
Activated T cells can be identified immunohistochemically in the intestinal lamina propria in a number of gastrointestinal diseases including food sensitive enteropathy (coeliac disease) and intractable diarrhoea of infancy. Experimental studies have shown that T cell activation in human intestinal lamina propria in vitro produces an increase in crypt cell proliferation, villous atrophy, increased HLA-DR expression on enterocytes, increased intraepithelial lymphocyte numbers, and, phenotypically, macrophage activation. All of these features are seen in food sensitive enteropathy and it is proposed that lamina propria T cell activation to food antigens plays the primary role in the pathogenesis of these disorders by altering mucosal morphology and the rate of epithelial cell proliferation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0012-2823
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46 Suppl 2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
290-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2262061-Food Hypersensitivity,
pubmed-meshheading:2262061-Gastrointestinal Diseases,
pubmed-meshheading:2262061-Humans,
pubmed-meshheading:2262061-Inflammatory Bowel Diseases,
pubmed-meshheading:2262061-Intestinal Mucosa,
pubmed-meshheading:2262061-Lymphocyte Activation,
pubmed-meshheading:2262061-T-Lymphocyte Subsets,
pubmed-meshheading:2262061-T-Lymphocytes
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
The role of activated T cells in transformed intestinal mucosa.
|
| pubmed:affiliation |
Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article
|