| pubmed-article:2262060 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C0021839 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C1185625 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:2262060 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:2262060 | pubmed:dateCreated | 1991-2-7 | lld:pubmed |
| pubmed-article:2262060 | pubmed:abstractText | Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal growth will be discussed. Lymphocytes from human and nonhuman primate intestine were isolated by an enzymatic procedure. Lymphocytes were studied using dual-color immunofluorescence (FACS) and functional in vitro assays. CD4 positive (helper-) lamina propria T-cells lack the CD45RA antigen and express the CD45RO antigen. This phenotype is characteristic for memory T cells. In addition intestinal T cells express IL-2 receptors and IL-2 receptor mRNA, and are able to synthesize high amounts of IL-2. Functional studies in nonhuman primates infected rectally with Chlamydia trachomatis have shown that lamina propria T cells do not proliferate after stimulation with antigen but rather provide helper function for immunoglobulin synthesis. The intestinal lamina propria therefore contains highly specialized T cells which have the phenotype of memory T cells and which are activated. Functionally these T cells can be characterized as differentiated effector lymphocytes. Recent studies from other laboratories have shown that the pattern of lymphokines produced by lamina propria T cells and the responsiveness to certain lymphokines also differ from those of other lymphocyte populations. Since T-cell-derived lymphokines are also important regulators for epithelial growth and differentiation as well as for connective tissue metabolism, lamina propria T cells might be of major importance in mucosal growth and transformation. | lld:pubmed |
| pubmed-article:2262060 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2262060 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262060 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2262060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2262060 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2262060 | pubmed:issn | 0012-2823 | lld:pubmed |
| pubmed-article:2262060 | pubmed:author | pubmed-author:JamesS PSP | lld:pubmed |
| pubmed-article:2262060 | pubmed:author | pubmed-author:RieckenE OEO | lld:pubmed |
| pubmed-article:2262060 | pubmed:author | pubmed-author:ZeitzMM | lld:pubmed |
| pubmed-article:2262060 | pubmed:author | pubmed-author:Schieferdecke... | lld:pubmed |
| pubmed-article:2262060 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2262060 | pubmed:volume | 46 Suppl 2 | lld:pubmed |
| pubmed-article:2262060 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2262060 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2262060 | pubmed:pagination | 280-9 | lld:pubmed |
| pubmed-article:2262060 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:meshHeading | pubmed-meshheading:2262060-... | lld:pubmed |
| pubmed-article:2262060 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2262060 | pubmed:articleTitle | Special functional features of T-lymphocyte subpopulations in the effector compartment of the intestinal mucosa and their relation to mucosal transformation. | lld:pubmed |
| pubmed-article:2262060 | pubmed:affiliation | Department of Gastroenterology, Klinikum Steglitz, Free University of Berlin. | lld:pubmed |
| pubmed-article:2262060 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2262060 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:2262060 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2262060 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2262060 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2262060 | lld:pubmed |
