Linked Life Data

2262060

Source:http://linkedlifedata.com/resource/pubmed/id/2262060

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-2-7
pubmed:abstractText
Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal growth will be discussed. Lymphocytes from human and nonhuman primate intestine were isolated by an enzymatic procedure. Lymphocytes were studied using dual-color immunofluorescence (FACS) and functional in vitro assays. CD4 positive (helper-) lamina propria T-cells lack the CD45RA antigen and express the CD45RO antigen. This phenotype is characteristic for memory T cells. In addition intestinal T cells express IL-2 receptors and IL-2 receptor mRNA, and are able to synthesize high amounts of IL-2. Functional studies in nonhuman primates infected rectally with Chlamydia trachomatis have shown that lamina propria T cells do not proliferate after stimulation with antigen but rather provide helper function for immunoglobulin synthesis. The intestinal lamina propria therefore contains highly specialized T cells which have the phenotype of memory T cells and which are activated. Functionally these T cells can be characterized as differentiated effector lymphocytes. Recent studies from other laboratories have shown that the pattern of lymphokines produced by lamina propria T cells and the responsiveness to certain lymphokines also differ from those of other lymphocyte populations. Since T-cell-derived lymphokines are also important regulators for epithelial growth and differentiation as well as for connective tissue metabolism, lamina propria T cells might be of major importance in mucosal growth and transformation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0012-2823
pubmed:author
pubmed:issnType
Print
pubmed:volume
46 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
280-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Special functional features of T-lymphocyte subpopulations in the effector compartment of the intestinal mucosa and their relation to mucosal transformation.
pubmed:affiliation
Department of Gastroenterology, Klinikum Steglitz, Free University of Berlin.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't