|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016315,
umls-concept:C0018787,
umls-concept:C0030685,
umls-concept:C0036226,
umls-concept:C0063477,
umls-concept:C0391871,
umls-concept:C0449432,
umls-concept:C0521115,
umls-concept:C0521116,
umls-concept:C0596235,
umls-concept:C0597484,
umls-concept:C0678640,
umls-concept:C0680255,
umls-concept:C1179435,
umls-concept:C1283071,
umls-concept:C1413043,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1963578,
umls-concept:C2003851,
umls-concept:C2334101
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1991-2-1
|
|
pubmed:abstractText |
Simultaneous measurements of intracellular Ca2(+)-concentration ([Ca2+]i) using Indo-1 and the current generated by electrogenic Na+/Ca2(+)-exchange (INaCa) have been performed on atrial myocytes from hearts of adult guinea-pigs. Whereas the fluorescence-measurements provide information on global [Ca2+]i, InaCa which is a linear function of Ca2(+)-concentration, indicates subsarcolemmal [Ca2+]. Under conditions in which intracellular Ca2(+)-transients due to Ca2(+)-release from the sarcoplasmic reticulum (SR) have been artificially slowed, a deviation between the two different Ca2(+)-signals can be found. During onset of release signals Ca2(+)-concentration seen by the membrane is higher than global [Ca2+]i. Our results provide evidence that in atrial myocytes, lacking a T-system, Ca2(+)-induced Ca2(+)-release occurs first from a subsarcolemmal compartment of the SR. The resulting Ca2(+)-transient serves to trigger Ca2(+)-release from deeper SR-compartments.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
275
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
181-4
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:2261988-Animals,
pubmed-meshheading:2261988-Calcium,
pubmed-meshheading:2261988-Carrier Proteins,
pubmed-meshheading:2261988-Cells, Cultured,
pubmed-meshheading:2261988-Cytosol,
pubmed-meshheading:2261988-Electric Conductivity,
pubmed-meshheading:2261988-Fluorescence,
pubmed-meshheading:2261988-Guinea Pigs,
pubmed-meshheading:2261988-Heart Atria,
pubmed-meshheading:2261988-Indoles,
pubmed-meshheading:2261988-Membrane Potentials,
pubmed-meshheading:2261988-Myocardium,
pubmed-meshheading:2261988-Sarcolemma,
pubmed-meshheading:2261988-Sarcoplasmic Reticulum,
pubmed-meshheading:2261988-Sodium-Calcium Exchanger
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Simultaneous recording of Indo-1 fluorescence and Na+/Ca2+ exchange current reveals two components of Ca2(+)-release from sarcoplasmic reticulum of cardiac atrial myocytes.
|
|
pubmed:affiliation |
Institut für Zellphysiologie, Ruhr-Universität, Bochum, FRG.
|
|
pubmed:publicationType |
Journal Article
|
