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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-2-7
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pubmed:abstractText |
The in vitro collagenolytic and proteoglycanasic activity from human fibrillated osteoarthritic cartilage was determined using labelled proteoglycans and type II collagen as substrates. In vitro, a glycosaminoglycan-peptide complex (GP-C Rumalon) induced a dose-dependent inhibition of both collagenolytic and proteoglycanasic activities while sodium salicylate and indomethacin had only a weak suppressive effect on proteoglycanase. Phospholipase A2 activity was unmodified by GP-C suggesting that the effect of the drug on degradative enzymes was unrelated to prostaglandin formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0770-3198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2261738-Aged,
pubmed-meshheading:2261738-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:2261738-Cartilage, Articular,
pubmed-meshheading:2261738-Collagen,
pubmed-meshheading:2261738-Dose-Response Relationship, Drug,
pubmed-meshheading:2261738-Endopeptidases,
pubmed-meshheading:2261738-Female,
pubmed-meshheading:2261738-Femur Head,
pubmed-meshheading:2261738-Humans,
pubmed-meshheading:2261738-Male,
pubmed-meshheading:2261738-Metalloendopeptidases,
pubmed-meshheading:2261738-Middle Aged,
pubmed-meshheading:2261738-Osteoarthritis,
pubmed-meshheading:2261738-Phospholipases A,
pubmed-meshheading:2261738-Phospholipases A2,
pubmed-meshheading:2261738-Tissue Extracts
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pubmed:year |
1990
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pubmed:articleTitle |
Study of the effect of a glycosaminoglycan-peptide complex on the degradative enzyme activities in human osteoarthritic cartilage.
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pubmed:affiliation |
Laboratoire d'Exploration Articulaire, Hôpital Edouard Herriot, Lyon, France.
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pubmed:publicationType |
Journal Article
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