Linked Life Data

2255206

Source:http://linkedlifedata.com/resource/pubmed/id/2255206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-1-24
pubmed:abstractText
A 50% ethanol extract of Coscinium fenestratum stem material (AECF) has been found to possess hypotensive action in anaesthetised dogs, rats and guinea pigs in a dose-related pattern. The fall in blood pressure was not modified by alpha and beta adrenergic blockers, cholinergic and histaminergic antagonists or by ganglion blocking agents. The effect was more pronounced in spinal-transected animals. AECF non-specifically inhibited the pressor responses to epinephrine, norepinephrine, DMPP and depressor responses to acetylcholine and histamine. AECF failed to exhibit any hypotension when administered via cannula into the lateral cerebral ventricle. Given orally to mice, AECF did not exhibit grossly observable central nervous effects up to doses of 800 mg/kg. The oral LD50 was estimated to be 1200 mg/kg in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0378-8741
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Hypotensive action of a Coscinium fenestratum stem extract.
pubmed:affiliation
Pharmacology Department, Regional Research Laboratory, Jammu Tawi, India.
pubmed:publicationType
Journal Article