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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1991-1-23
|
| pubmed:abstractText |
Potential risk factors have been examined for association with mortality over a 10-12 year follow-up of the patients of the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics (aged 35-54 years at entry to the study). Proteinuria has the strongest association with all-cause mortality in univariate analysis being significant in patients of both sexes with Type 2 (non-insulin-dependent) diabetes mellitus and in women with Type 1 (insulin-dependent) diabetes mellitus; both systolic blood pressure (men) and hypertension (both sexes) (as a categorical variable) are significant in Type 1 diabetes. Hypertension is also significantly associated with all-cause mortality in multivariate analysis in both sexes with Type 1 diabetes as proteinuria is in women with Type 2 diabetes. There is an unexpected negative association between plasma creatinine and all-cause mortality in men with Type 2 diabetes. Systolic blood pressure and hypertension are also significantly linked with cardiovascular mortality in Type 1 diabetes, hypertension having an estimated relative risk of 4.6 [corrected] in multivariate analysis. Serum cholesterol and proteinuria showed the strongest associations with cardiovascular mortality in Type 2 diabetes. Proteinuria is associated with non-cardiovascular mortality in both types of diabetes in univariate but not multivariate analysis. In multivariate analysis hypertension (Type 1 diabetes) and diabetes duration (Type 2 diabetes) are associated with non-cardiovascular mortality. Hypertension and proteinuria have the most consistent associations with mortality in the different analyses with the effect of hypertension appearing stronger in Type 1 diabetes and proteinuria in Type 2 diabetes.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
542-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2253831-Adult,
pubmed-meshheading:2253831-Analysis of Variance,
pubmed-meshheading:2253831-Blood Pressure,
pubmed-meshheading:2253831-Cardiovascular Diseases,
pubmed-meshheading:2253831-Cholesterol,
pubmed-meshheading:2253831-Cohort Studies,
pubmed-meshheading:2253831-Diabetes Complications,
pubmed-meshheading:2253831-Diabetes Mellitus,
pubmed-meshheading:2253831-Diabetes Mellitus, Type 1,
pubmed-meshheading:2253831-Diabetes Mellitus, Type 2,
pubmed-meshheading:2253831-Female,
pubmed-meshheading:2253831-Humans,
pubmed-meshheading:2253831-Hypertension,
pubmed-meshheading:2253831-London,
pubmed-meshheading:2253831-Male,
pubmed-meshheading:2253831-Middle Aged,
pubmed-meshheading:2253831-Prospective Studies,
pubmed-meshheading:2253831-Regression Analysis,
pubmed-meshheading:2253831-Risk Factors,
pubmed-meshheading:2253831-World Health Organization
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
A prospective study of mortality among middle-aged diabetic patients (the London Cohort of the WHO Multinational Study of Vascular Disease in Diabetics) II: Associated risk factors.
|
| pubmed:affiliation |
Unit for Metabolic Medicine, United Medical School (Guy's Campus), London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|