Linked Life Data

2253827

Source:http://linkedlifedata.com/resource/pubmed/id/2253827

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1991-1-23
pubmed:abstractText
In order to assess the extent to which the progression of diabetic glomerulopathy can be arrested or reversed by improved glycaemic control, glomerular structure has been assessed in dogs randomly divided between a non-diabetic group and three alloxan diabetic groups: dogs assigned to poor glycaemic control for five years (PC), dogs assigned to good glycaemic control for five years (GC), and dogs assigned to poor glycaemic control for 2.5 years followed by good glycaemic control for 2.5 years (P----GC). Glomerular volume, the fractional volume of mesangium as estimated by light microscopy and thickness of glomerular basement membrane as estimated by electron microscopy were significantly greater than normal at 2.5 years of poor glycaemic control, and were even greater at five years. Kidney weight and the frequency of glomerular obliteration were significantly greater than normal at five years of poor control. The development of these renal abnormalities was significantly inhibited if good glycaemic control was begun within the first weeks of diabetes. Good control following 2.5 years of poor control (group P----GC) arrested the progression of the renal abnormalities, but no reversal of the lesions toward normal was apparent.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Arrest of glomerulopathy in diabetic dogs by improved glycaemic control.
pubmed:affiliation
Department of Ophthalmology, University of Wisconsin, Madison.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't