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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1991-1-24
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pubmed:abstractText |
The influence of cholinergic blockade as well as vagal denervation of the oxyntic gland mucosa on the gastrin response to gastrin-releasing peptide (GRP) have been studied in patients with duodenal ulcer disease. The gastric luminal content was neutralized during the experiments. GRP induced a substantial increase in gastrin levels with a peak response already after 15 min of infusion. Vagal denervation of the parietal cell area induced a significant increase in basal gastrin concentrations and a significant enhancement of the GRP response. Two different doses of benzilonium bromide were studied and neither influenced the basal concentrations of gastrin. A significantly increased gastrin response to GRP was, however, observed after administration of both a high and a very low dose of the anticholinergic drug. Our results delineate a vagal, noncholinergic inhibitory influence on the basal gastrin release. In addition a vagally dependent oxyntopyloric mechanism inhibits the gastrin release stimulated by GRP. This inhibitory mechanism may hypothetically be a cholinergic reflex mechanism.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bombesin,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrin-Releasing Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrins,
http://linkedlifedata.com/resource/pubmed/chemical/Parasympatholytics,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/benzilonium bromide
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pubmed:status |
MEDLINE
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pubmed:issn |
0012-2823
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2253822-Bombesin,
pubmed-meshheading:2253822-Duodenal Ulcer,
pubmed-meshheading:2253822-Female,
pubmed-meshheading:2253822-Gastrin-Releasing Peptide,
pubmed-meshheading:2253822-Gastrins,
pubmed-meshheading:2253822-Humans,
pubmed-meshheading:2253822-Male,
pubmed-meshheading:2253822-Middle Aged,
pubmed-meshheading:2253822-Parasympatholytics,
pubmed-meshheading:2253822-Peptides,
pubmed-meshheading:2253822-Pyrrolidines,
pubmed-meshheading:2253822-Vagotomy, Proximal Gastric
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pubmed:year |
1990
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pubmed:articleTitle |
Effect of parietal cell vagotomy and cholinergic blockade on gastrin release in man induced by gastrin-releasing peptide.
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pubmed:affiliation |
Department of Surgery, Sahlgren's Hospital, University of Gothenburg, Sweden.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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