Linked Life Data

2253401

Source:http://linkedlifedata.com/resource/pubmed/id/2253401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-1-24
pubmed:abstractText
The effect of oral contraceptives and of pregnancy on the daily rhythm of cortisol, and its metabolite cortisone in plasma and saliva has been investigated. In both conditions the total plasma cortisol levels were raised to the same extent, the mean values in saliva in the oral contraceptive users being intermediate between those in pregnancy and in the controls, particularly in the morning. Salivary cortisone levels were more related to salivary cortisol than to total plasma cortisone which exhibited a rather flat daily rhythm. There was a shift in peak values for salivary cortisol and cortisone towards late morning: this may be due to a delay in the daily activation of the hypothalamic-pituitary-adrenal axis in these patients.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/ADRENAL CORTEX HORMONES, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive..., http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System, http://linkedlifedata.com/resource/pubmed/keyword/Estrogens--pharmacodynamics, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Hormones, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives..., http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--pharmacodynamics, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy--pharmacodynamics, http://linkedlifedata.com/resource/pubmed/keyword/Reproduction, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-8981
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
190
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-21
pubmed:dateRevised
2004-11-17
pubmed:otherAbstract
PIP: The daily rhythm of plasma free cortisol and its metabolite cortisone in pregnancy or during oral contraceptive (OC) use was investigated in 10 pregnant women, 11 users of low-dose OCs, and 12 nonpregnant controls who were not using OCs. Radioimmunoassay was performed in the analysis of citric-acid stimulated saliva samples collected from 5 AM to midnight at 1-2-hour intervals and plasma samples were obtained from 10 women. Both pregnancy and OC use were found to produce significantly elevated levels of salivary cortisol and cortisone as well as a delay in the peak time of each hormone. The plasma analyses revealed significant increases in cortisol concentrations in both pregnant women and OC users, but plasma concentrations of cortisone increased only in pregnant women. Peak concentrations of salivary and total plasma cortisol were significantly higher in the first half of pregnancy, while cortisone was significantly higher during the second half of pregnancy. The shift in the peak of cortisone and cortisol values was from about 7 AM in control to 8 AM during pregnancy, with OC users in an intermediate position. Unexpectedly, the values for free plasma cortisol were normal during the afternoon but raised in saliva. It is postulated that the observed shifts in the peak time of the daily rhythm of cortisol and cortisone during pregnancy and OC use reflect an estrogen-induced increased synthesis of corticosteroid-binding globulin. Of interest would be a 24-hour measurement of these two hormones in saliva, free plasma, and total plasma.
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The effect of oral contraceptive use and pregnancy on the daily rhythm of cortisol and cortisone.
pubmed:affiliation
Department of Medicine, St. Radboud Hospital, Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article