Linked Life Data

225288

Source:http://linkedlifedata.com/resource/pubmed/id/225288

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1979-11-21
pubmed:abstractText
Adenovirus types 8 and 19 are responsible for a large number of cases of acute follicular conjunctivitis, mainly in the form of epidemic keratoconjunctivitis (EKC). This study successfully demonstrates the establishment of adenovirus infection in rabbit corneal organ cultures. Normal rabbit corneas were maintained in culture without significant morphologic alterations for up to 7 weeks. Adenovirus types 8 and 19 replication in rabbit corneas was demonstrated by viral growth curves and subpassage studies. Intracellular localization of adenoviral antigens was confirmed with immunofluorescent techniques. The characteristic cytopathic effects of adenoviral infection were observed with the use of various histochemical stains. Thus an in vitro corneal organ culture model was established for the study of the pathogenesis of corneal lesions in adenovirus EKC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
956-63
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Adenovirus types 8 and 19 infection of rabbit corneal organ cultures.
pubmed:publicationType
Journal Article, In Vitro