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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1991-1-17
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pubmed:abstractText |
Distinct alterations in the rate of DNA synthesis (an increase in the rate of reparation and a decrease in the rate of replication in nuclei and mitochondria) were detected in liver and brain cells during the stress caused by surgical operation. Within 8-10 hrs after the operation the rate of DNA reparation was increased by 40-50% in nuclei of liver cells and by 31-35% in brain cell nuclei. Replication of nuclear DNA was decreased immediately after the operation--by 33% in liver cells and by 50% in brain cells. Within a day after the operation the rate of replication was restored up to the control level in liver cells, while it was still decreased by 30% in brain cells. The rate of mitochondrial DNA synthesis was slightly decreased within the first 12 hrs after the operation: by 12-14% in liver cells and by 18-20% in brain cells. The stress, and particularly postoperative stress, exhibited pronounced action on structure and various systems of DNA synthesis in cells of various tissues.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0042-8809
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2251802-Animals,
pubmed-meshheading:2251802-Brain,
pubmed-meshheading:2251802-Cell Nucleus,
pubmed-meshheading:2251802-DNA,
pubmed-meshheading:2251802-DNA, Mitochondrial,
pubmed-meshheading:2251802-DNA Repair,
pubmed-meshheading:2251802-Liver,
pubmed-meshheading:2251802-Postoperative Complications,
pubmed-meshheading:2251802-Rats,
pubmed-meshheading:2251802-Rats, Inbred Strains,
pubmed-meshheading:2251802-Stress, Psychological
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pubmed:articleTitle |
[The effect of surgical stress on DNA synthesis in liver and brain cells].
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pubmed:publicationType |
Journal Article,
English Abstract
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