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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1991-1-15
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pubmed:abstractText |
Susceptibility to autoimmune orchitis is associated with an immune response (Ir) gene (now designated Orch-1) which was preliminarily shown to reside at or near the H-2D subregion of the major histocompatibility complex in the mouse (H-2). In this study, the role of H-2 in controlling both disease susceptibility and the phenotypic expression of infertility associated with autoimmune orchitis has been significantly extended. Of nine C57BL/10SnJ and three BALB/cAnN H-2 congenic strains, only those mice possessing the H-2d, H-2p haplotypes exhibited autoimmune orchitis accompanied by infertility. All other congenic strains, including those expressing the H-2 haplotypes v, q, b, s, r, f, and k were of the low responder phenotype. In addition, disease susceptibility was found to be inherited as a dominant trait in H-2 congenic F1 hybrid mice. In order to map the precise location of the Orch-1 locus within H-2, 32 intra-H-2 recombinant congenic strains possessing defined crossovers in various locations throughout the H-2 region were studied. The results of the analysis indicate that Orch-1 maps within the interval between the H-2S and H-2D regions. Our results also indicate that class II genes, i.e., A and E region-encoded genes, have little discernable effect in controlling disease susceptibility and resistance despite the fact that testicular lesions can be adoptively transferred with Ia-restricted CD4+ effector T cells. A comparison of the Orch-1 alleles with the genotypes of two additional markers which map within the H-2S/H-2D interval suggests the following gene order: H-2S--TNP-Ficoll--Orch-1--Tnfa--H-2D.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0093-7711
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:geneSymbol |
H-2,
Ir,
Orch-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-44
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2249881-Alleles,
pubmed-meshheading:2249881-Animals,
pubmed-meshheading:2249881-Autoimmune Diseases,
pubmed-meshheading:2249881-Disease Models, Animal,
pubmed-meshheading:2249881-Disease Susceptibility,
pubmed-meshheading:2249881-Fertility,
pubmed-meshheading:2249881-Genes, MHC Class I,
pubmed-meshheading:2249881-Male,
pubmed-meshheading:2249881-Mice,
pubmed-meshheading:2249881-Orchitis,
pubmed-meshheading:2249881-Recombination, Genetic,
pubmed-meshheading:2249881-Testis
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pubmed:year |
1990
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pubmed:articleTitle |
Experimental allergic orchitis in mice. VI. Recombinations within the H-2S/H-2D interval define the map position of the H-2-associated locus controlling disease susceptibility.
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pubmed:affiliation |
Division of Reproductive Biology, University of Pennsylvania School of Medicine, Philadelphia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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