Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1991-1-11
pubmed:abstractText
To examine the restriction of HIV growth in murine cells, we infected NIH 3T3 cells with HIV pseudotyped by Moloney murine leukemia virus. The virus, which carried a dominant selectable marker under the control of the HIV LTR, gave large numbers of resistant clones, showing that murine cells are permissive for HIV uncoating, reverse transcription, nuclear transport and integration. However, we found that several murine cell lines, as well as CHO cells, could not support the function of rev, the viral regulatory gene which, in human cells, induces the cytoplasmic expression of the incompletely spliced class of HIV mRNAs that encode the viral structural proteins. Transfection of the HIV-infected murine cells with a HTLV-1 rex-expressing vector failed to rescue the rev- phenotype, indicating that the block extended to rex function. Most importantly, we could complement the rev defect by fusing the infected murine with uninfected human cells. We conclude that HIV tropism is partly a consequence of a trans-acting cellular factor critical for Rev function.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-1691314, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2305256, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2364429, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2541919, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2676192, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2683071, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2704072, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2784208, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2835230, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2836612, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-2836628, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3010461, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3012355, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3035544, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3047430, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3048703, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3054879, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3094962, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3174625, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3260352, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3262832, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3412474, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3413107, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3638988, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-3670292, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6251549, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6331674, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6409419, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6573667, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6587390, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6757385, http://linkedlifedata.com/resource/pubmed/commentcorrection/2249669-6960240
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4155-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
A human cell factor is essential for HIV-1 Rev action.
pubmed:affiliation
Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.