Linked Life Data

2249424

Source:http://linkedlifedata.com/resource/pubmed/id/2249424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1991-1-17
pubmed:abstractText
To verify a structured model of the glucose-insulin system, metabolic measurements were compared with model-based simulations in insulin-dependent diabetic dogs which had been previously identified in terms of model parameters. Glycaemia, glucosuria, plasma insulin, and the rates of appearance Ra and disappearance Rd of glucose (kinetics of double-labelled glucose, evaluated according to Steele's equation in its non-steady-state version) were observed under the following conditions, starting from normoglycaemia during glucose-controlled insulin infusion (GCII): (I) insulin withdrawal, (II) insulin withdrawal and glucose infusion, (III) constant i.v. infusion of glucose and insulin, (IV) glucose infusion during GCII. After fitting the patterns of glycaemia, simulations of the other state variables were accomplished, employing the individual model parameters, the preset experimental inputs, and the GCII control constants (test IV only). Under nearly all conditions, correspondence was excellent between measured and simulated data. There were, however, the following exceptions: incomplete representation by the model of kinetics in glucose utilisation after interruption of insulin supply, overestimation of glucosuria by the model in the presence of insulin. It is concluded that the model provides a reasonable representation of metabolic processes which are of importance in the treatment of insulin-dependent diabetes mellitus and that it might thus appropriately simulate the outcome of metabolic regimens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0169-2607
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-58
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Experimental validation of a glucose-insulin control model to stimulate patterns in glucose turnover.
pubmed:affiliation
Central Institute of Diabetes Gerhardt Katsch, Karlsburg, G.D.R.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't