Linked Life Data

2249317

Source:http://linkedlifedata.com/resource/pubmed/id/2249317

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-1-15
pubmed:abstractText
Acute lung injury induced by intravenous infusion of zymosan-activated plasma(ZAP) on Wistar rats was studied. A single infusion of ZAP resulted in an early occurrence of increased respiratory rate, decreased PaO2, elevated activity of superoxide dismutase(SOD) in the arterial blood and lung tissue. The results showed that the content of copperzinic superoxide dismutase(Cu Zn SOD) in bronchiolar columnar epithelial cells was elevated. Histological and electron microscopic examination showed that there was an accumulation of neutrophils in pulmonary microvessels and capillaries, endothelial cell and epithelial cell injury, and pulmonary edema etc. The tight junctions both in the epithelium and endothelium showed alterations in substructure including discontinuity, irregularity, free ends and distention of meshes as early as 2 to 4 h. In later stage, the severity of damage of tight junctions increased, while the number of strands in endothelial junctions reduced. All the parameters in the control group did not change significantly. From the results, the authors consider that acute lung injury is intimately related to the neutrophils and oxygen free radicals, the pathological basis of early pulmonary edema is alterations in the tight junctions of the alveolar epithelium and capillary endothelium.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1001-0939
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-51, 190
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Pathoanatomical and pathophysiological study of lung injury induced by activated complement in rat].
pubmed:affiliation
Department of pathology, 304 Hospital.
pubmed:publicationType
Journal Article, English Abstract