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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1991-1-17
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pubmed:abstractText |
Preclinical data showed that the cytotoxic effects of 5-fluorouracil (5-FU) are augmented by interferon (IFN). In a small study, 13 of 17 patients with advanced colorectal cancer responded to a regimen of 5-FU with IFN. Using the same dose and schedule as in this pilot study, 38 previously untreated patients with metastatic colorectal carcinoma were treated with continuous intravenous (IV) infusion of 5-FU 750 mg/m2 daily for 5 days, followed by weekly bolus 5-FU at 750 mg/m2 and subcutaneous IFN at 9 million units three times per week. Of 35 evaluable patients, nine (26%) had a partial response (95% confidence limit, 11% to 41%), with a median response duration of 7.5 months (range, 4.4 to greater than 11.7 months). Seven patients (20%) had a minor response, and ten (28%) had stable disease. The most common toxicities observed were stomatitis (52%) and diarrhea (43%). Neurotoxicity was seen in 34% of patients and consisted of gait disturbance, dizziness, confusion, memory loss, and dementia. Because of toxicity, 84% of patients required a reduction of the IFN dose by at least 50%, and 63% required reduction of the 5-FU dose by at least 25%. Although the combination of 5-FU and IFN in patients with advanced colorectal carcinoma has some activity, the regimen was toxic, and the observed response rate (26%) was not substantially superior to alternative 5-FU programs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
66
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2470-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2249187-Adult,
pubmed-meshheading:2249187-Aged,
pubmed-meshheading:2249187-Colorectal Neoplasms,
pubmed-meshheading:2249187-Drug Therapy, Combination,
pubmed-meshheading:2249187-Female,
pubmed-meshheading:2249187-Fluorouracil,
pubmed-meshheading:2249187-Humans,
pubmed-meshheading:2249187-Infusions, Intravenous,
pubmed-meshheading:2249187-Interferon-alpha,
pubmed-meshheading:2249187-Male,
pubmed-meshheading:2249187-Middle Aged,
pubmed-meshheading:2249187-Recombinant Proteins
|
pubmed:year |
1990
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pubmed:articleTitle |
Interferon alpha-2a and 5-fluorouracil for advanced colorectal carcinoma. Assessment of activity and toxicity.
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pubmed:affiliation |
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
|
pubmed:publicationType |
Journal Article,
Clinical Trial
|