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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1991-1-7
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pubmed:abstractText |
A boy aged 4 with penoscrotal hypospadias and his brother aged 12 with micropenis had typical changes of homozygous 5 alpha-reductase deficiency. After three injections of chorionic gonadotrophin there was a trivial rise in plasma dihydrotestosterone with a normal increase in plasma testosterone. Urine steroid chromatography showed abnormally high 5 beta: 5 alpha ratios and 5 alpha-reductase activity was appreciably reduced in genital skin fibroblasts. The results indicate that 5 alpha-reductase deficiency is not invariably associated with genital ambiguity.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1468-2044
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1166-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2248513-3-Oxo-5-alpha-Steroid 4-Dehydrogenase,
pubmed-meshheading:2248513-Child,
pubmed-meshheading:2248513-Child, Preschool,
pubmed-meshheading:2248513-Chorionic Gonadotropin,
pubmed-meshheading:2248513-Dihydrotestosterone,
pubmed-meshheading:2248513-Humans,
pubmed-meshheading:2248513-Hypospadias,
pubmed-meshheading:2248513-Isomerism,
pubmed-meshheading:2248513-Male,
pubmed-meshheading:2248513-Penis,
pubmed-meshheading:2248513-Skin,
pubmed-meshheading:2248513-Testosterone,
pubmed-meshheading:2248513-Tetrahydrocortisol
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pubmed:year |
1990
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pubmed:articleTitle |
5 alpha-reductase deficiency without hypospadias.
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pubmed:affiliation |
Hospital for Sick Children, London.
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pubmed:publicationType |
Journal Article,
Case Reports
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