Linked Life Data

2247768

Source:http://linkedlifedata.com/resource/pubmed/id/2247768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-1-8
pubmed:abstractText
Diurnal and monthly variability of the serum concentration of lipids, lipoproteins and apoproteins were examined in 11 healthy subjects aged 32-63 (mean 46) years. For diurnal measurements, blood samples were drawn at 0800, 1200, 1500, 1800, and 2100 hours. The variability over 1 month was assessed from four analyses taken weekly at 0800 hours after at least 8 h fast. The analytical variability expressed as mean coefficient of variation (CV) ranged from 0.95% for cholesterol to 7.6% for apoprotein B. The mean CVs for diurnal biological variability were 2.4% for cholesterol, 3.5% for HDL-cholesterol, 5.1% for LDL-cholesterol, 29.5% for triglycerides, 6.5% for apoprotein A and 6.5% for apoprotein B. The respective biological CVs for monthly variability were 4.2%, 4.1%, 5.2%, 20.7%, 9.4% and 9.7%. A repeated-measures ANOVA revealed a significant increase of triglycerides (p less than 0.01) and decrease of LDL-cholesterol (p less than 0.01) during the day. Within 1 month, apoprotein A tended to rise (0.05 less than p less than 0.10). Although the best reproducibility was found for cholesterol, the results obtained indicate that six tests have to be taken before and after intervention by drug or diet to detect a reduction of 10% in an individual with a probability of 0.95.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0036-5513
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
635-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Diurnal and monthly intra-individual variability of the concentration of lipids, lipoproteins and apoproteins.
pubmed:affiliation
Medical Department, Vestfold Central Hospital, Tønsberg, Norway.
pubmed:publicationType
Journal Article