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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
6300
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|
pubmed:dateCreated |
1991-1-7
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|
pubmed:abstractText |
CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4 determined at 2.3 A resolution reveals that the molecule has two intimately associated immunoglobulin-like domains. Residues implicated in HIV recognition by analysis of mutants and antibody binding are salient features in domain D1. Domain D2 is distinguished by a variation on the beta-strand topologies of antibody domains and by an intra-sheet disulphide bridge.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
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pubmed:issn |
0028-0836
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
348
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
N
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pubmed:pagination |
419-26
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2247146-Amino Acid Sequence,
pubmed-meshheading:2247146-Antibodies, Monoclonal,
pubmed-meshheading:2247146-Antigens, CD4,
pubmed-meshheading:2247146-Binding Sites,
pubmed-meshheading:2247146-Biological Evolution,
pubmed-meshheading:2247146-Computer Graphics,
pubmed-meshheading:2247146-Crystallography,
pubmed-meshheading:2247146-DNA Mutational Analysis,
pubmed-meshheading:2247146-HIV Envelope Protein gp120,
pubmed-meshheading:2247146-HLA-D Antigens,
pubmed-meshheading:2247146-Membrane Fusion,
pubmed-meshheading:2247146-Models, Molecular,
pubmed-meshheading:2247146-Molecular Sequence Data,
pubmed-meshheading:2247146-Molecular Structure,
pubmed-meshheading:2247146-Peptide Fragments,
pubmed-meshheading:2247146-Protein Conformation,
pubmed-meshheading:2247146-Recombinant Proteins,
pubmed-meshheading:2247146-Structure-Activity Relationship,
pubmed-meshheading:2247146-X-Ray Diffraction
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pubmed:year |
1990
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pubmed:articleTitle |
Crystal structure of an HIV-binding recombinant fragment of human CD4.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
