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rdf:type |
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lifeskim:mentions |
umls-concept:C0023317,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0040078,
umls-concept:C0086860,
umls-concept:C0205145,
umls-concept:C0205171,
umls-concept:C1517945,
umls-concept:C1879547,
umls-concept:C1948062,
umls-concept:C2003941,
umls-concept:C2713393
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pubmed:issue |
12
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|
pubmed:dateCreated |
1991-1-8
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|
pubmed:abstractText |
One copy of the mouse alpha A-crystallin gene alpha A-CRYBP1 site activated the thymidine kinase (tk) promoter in a mouse lens epithelial cell line but not in primary chicken lens cells; multiple copies further activated the tk promoter and extended expression to fibroblasts, B cells, and chicken lens cultures. The loss of lens specificity by multimerization may place selective constraints on the number of alpha A-CRYBP1 sites in the alpha A-crystallin promoter.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-1694016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2106471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2108316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2178867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2295367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2304470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2328840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2504707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2584197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2656357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2665943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2834246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2836068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-2844627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3013424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3038516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3052280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3141147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3170605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3322806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3422454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3474517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3561391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3857584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-3865198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-4119881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-6294651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2247086-6310564
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0270-7306
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6813-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2247086-Animals,
pubmed-meshheading:2247086-Base Sequence,
pubmed-meshheading:2247086-Binding Sites,
pubmed-meshheading:2247086-Cell Line,
pubmed-meshheading:2247086-Cells, Cultured,
pubmed-meshheading:2247086-Chick Embryo,
pubmed-meshheading:2247086-Crystallins,
pubmed-meshheading:2247086-Epithelium,
pubmed-meshheading:2247086-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:2247086-Lens, Crystalline,
pubmed-meshheading:2247086-Mice,
pubmed-meshheading:2247086-Molecular Sequence Data,
pubmed-meshheading:2247086-Oligonucleotide Probes,
pubmed-meshheading:2247086-Promoter Regions, Genetic,
pubmed-meshheading:2247086-Thymidine Kinase,
pubmed-meshheading:2247086-Transcription, Genetic,
pubmed-meshheading:2247086-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
Species-specific lens activation of the thymidine kinase promoter by a single copy of the mouse alpha A-CRYBP1 site and loss of tissue specificity by multimerization.
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pubmed:affiliation |
Laboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article
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