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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-4
|
| pubmed:dateCreated |
1991-1-10
|
| pubmed:abstractText |
Subpial complete resection of a 10 mm segment of the spinal cord at Th 9 was performed in 9 adult cats. Topographic enzyme histochemical investigations of the terminal clubs were performed after different survival times after transection in 7 cats and three days after a subsequent one-week-delayed autologous sciatic grafting procedure in the remaining two cats. For acid phosphatase (ACP), the count of active terminal clubs was high (200 per m2) from 12 hours until day 3 after transection. Then the count of active terminal clubs decreased to a low level (20 per m2) and remained the same until day 14. Removal of necrotic tissue and subsequent grafting with autologous sciatic nerve did not change these findings. For succinate dehydrogenase (SDH), the numbers of terminal clubs showed the same pattern at a lower level. The SDH defined terminal clubs were smaller than the ACP ones. The length of the SDH positive area decreased after 7 days while the ACP positive area remained the same until day 14. The SDH active terminal clubs are overgrown by the ACP positive terminal clubs, after the 7th day. Considering that SDH is linked to constructive activity in mitochondria and ACP to destructive activity in lysosomes, this phenomenon might be responsible for the termination of the capacity of the spinal cord tissue to regenerate.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0924-3860
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
404-17
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2245143-Acid Phosphatase,
pubmed-meshheading:2245143-Animals,
pubmed-meshheading:2245143-Cats,
pubmed-meshheading:2245143-Denervation,
pubmed-meshheading:2245143-Female,
pubmed-meshheading:2245143-Histocytochemistry,
pubmed-meshheading:2245143-Nerve Regeneration,
pubmed-meshheading:2245143-Nerve Tissue,
pubmed-meshheading:2245143-Spinal Cord,
pubmed-meshheading:2245143-Succinate Dehydrogenase
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Enzyme histochemistry of the spinal cord after experimental transection (Th 9) in the cat.
|
| pubmed:affiliation |
Department of Neurosurgery, Leiden University, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|