Linked Life Data

2242709

Source:http://linkedlifedata.com/resource/pubmed/id/2242709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-1-3
pubmed:abstractText
The effects of pharmacologic hyperinsulinemia on changes in plasma catecholamines, circulation and oxygen metabolism were examined in fetal sheep. Sequential incremental doses of 0.2 and 0.4 U.kg-1.h-1 of porcine insulin were infused into fetal sheep for 24 h each, for a total of 48 h; pharmacologic fetal insulin concentrations were achieved. Fetal hyperinsulinemia resulted in fetal hypoxemia on the basis of reduced umbilical venous oxygen content. Fetal oxygen extraction increased and oxygen uptake did not change. Prolonged fetal hyperinsulinemia with hypoxemia was also associated with hypoglycemia and a surge in fetal plasma catecholamine concentration. Heart rate and fetal body blood flow also increased. This increased blood flow to the fetal body resulted from increased blood flow to vital organs, including heart and adrenal glands, and insulin-sensitive tissues, including gastrointestinal tract and carcass, without reductions in blood flow to other fetal organs. These changes in regional vascular perfusion maintained oxygen delivery to individual fetal organs similar to values before insulin infusion. We conclude that the ovine fetus has a remarkable ability to compensate for pharmacologic hyperinsulinemia of 48 h duration, which resulted in hypoxemia, hypoglycemia, and a surge in plasma catecholamine concentration, and that appropriate fetal adaptations maintained fetal oxygen consumption and regional oxygen delivery to individual fetal organs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-8305
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-44
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of prolonged fetal hyperinsulinemia on plasma catecholamines, circulation and oxygen metabolism in utero.
pubmed:affiliation
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.