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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1990-12-17
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pubmed:abstractText |
From data available at April 1987 it was found that the standardised risk ratio for rheumatoid arthritis between current users of oral contraceptives and never users was 0.82 (95% confidence interval 0.59 to 1.15); the ratio between former users and never users was 0.94 (95% confidence interval 0.72 to 1.22). Important secular trends have occurred within our study population. The incidence of rheumatoid arthritis among former and never users has declined over the past two decades. Current users have not experienced this temporal trend, and the ratio between current and never users has, therefore, approached unity. These secular changes may explain why some studies have found that oral contraceptives have a protective effect, while others have been unable to show such an effect.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-2819340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-3621942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-3760110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-3779320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-3813667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-3944948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-4046123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-6126710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-6134094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-6740269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2241261-7352462
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Age Distribution,
http://linkedlifedata.com/resource/pubmed/keyword/Age Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Bias,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Case Control Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Error Sources,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Incidence--changes,
http://linkedlifedata.com/resource/pubmed/keyword/Literature Review,
http://linkedlifedata.com/resource/pubmed/keyword/Measurement,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Risk Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/United Kingdom
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-4967
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
744-6
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pubmed:dateRevised |
2009-11-18
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pubmed:otherAbstract |
PIP: From data available in April 1987, it was found that the standardized risk ratio for rheumatoid arthritis between current users of oral contraceptives (OCs) and never users was 0.82 (95% confidence interval ([CI] 0.59-1.15). The ratio between former users and never users was 0.94 (95% CI 0.72-1.22). Important secular trends have occurred within this study population. The incidence of rheumatoid arthritis among former and never users has declined over the past 2 decades. Current users have not experienced this temporal trend, and the ratio between current and never users has, therefore, approached unity. These secular changes may explain why some studies have found that OCs have a protective effect, while others have been unable to show such an effect.
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pubmed:meshHeading |
pubmed-meshheading:2241261-Adult,
pubmed-meshheading:2241261-Age Factors,
pubmed-meshheading:2241261-Arthritis, Rheumatoid,
pubmed-meshheading:2241261-Confidence Intervals,
pubmed-meshheading:2241261-Contraceptives, Oral,
pubmed-meshheading:2241261-Female,
pubmed-meshheading:2241261-Great Britain,
pubmed-meshheading:2241261-Humans,
pubmed-meshheading:2241261-Middle Aged,
pubmed-meshheading:2241261-Odds Ratio,
pubmed-meshheading:2241261-Risk Factors,
pubmed-meshheading:2241261-Time Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Oral contraceptives and rheumatoid arthritis: new data from the Royal College of General Practitioners' oral contraception study.
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pubmed:affiliation |
Royal College of General Practitioners, Manchester Research Unit.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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