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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1990-12-19
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pubmed:abstractText |
To evaluate CA 15-3, a new breast cancer associated antigen, and to compare it with carcinoembryonic antigen (CEA), all patients presenting with breast cancer had preoperative and serial (3-monthly) postoperative levels measured. Of 124 patients with primary breast cancer, 23% had an elevated CA 15-3 (greater than 25 units/ml) while 11% had an elevated CEA (greater than 5 ng/ml) (p = not significant). Neither marker was an indicator of spread to regional lymph nodes in primary breast cancer. In 45 recurrences of breast cancer, CA 15-3 was elevated at the time of first recurrence in 58% while CEA was elevated in 47% (p = not significant). Of 17 patients with locoregional recurrence alone, none had a CA 15-3 above 40 units/ml while 11 of 12 with synchronous locoregional and distant recurrence had a CA 15-3 level greater than 40 units/ml (chi 2: 21.36, p less than 0.0001). This study shows that CA 15-3, like CEA, is of little clinical value in primary breast cancer. CA 15-3, however, is an accurate indicator (overall accuracy, 97%) of synchronous distant metastases in patients with locoregional recurrence from breast cancer. This information has important implications for further investigation and management of such patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0364-2313
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
562-5; discussion 565-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2238654-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:2238654-Breast Neoplasms,
pubmed-meshheading:2238654-Carcinoembryonic Antigen,
pubmed-meshheading:2238654-Female,
pubmed-meshheading:2238654-Humans,
pubmed-meshheading:2238654-Lymphatic Metastasis,
pubmed-meshheading:2238654-Neoplasm Metastasis,
pubmed-meshheading:2238654-Neoplasm Recurrence, Local,
pubmed-meshheading:2238654-Predictive Value of Tests,
pubmed-meshheading:2238654-Tumor Markers, Biological
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pubmed:articleTitle |
CEA and CA 15-3 in primary and recurrent breast cancer.
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pubmed:affiliation |
Department of Surgery, University College Dublin, Woodview, Belfield, Ireland.
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pubmed:publicationType |
Journal Article,
Comparative Study
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