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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
1990-12-7
|
| pubmed:abstractText |
The secretion of luteinizing hormone (LH) by the pituitary gland is a pulsatile phenomenon. In the rhesus monkey, each pulse of LH in the peripheral circulation is associated with a characteristic increase in multiunit electrical activity (MUA) recorded from the medial basal hypothalamus. These "volleys" of electrical activity initiate the release of gonadotropin-releasing hormone (GnRH) into the pituitary portal circulation from the terminals of neurosecretory cells. Their duration varies from 1-3 min in normal, adult intact females to 10-25 min in long-term ovariectomized monkeys. A variety of pharmacological interventions also modify volley duration. The purpose of this investigation was to determine the physiological significance of alterations in volley duration. The dynamics of LH pulses in ovariectomized animals were observed in a number of experimental circumstances in which MUA volley duration was reduced from a maximum of 23 min to a minimum of 4 min without significantly altering their frequency. The magnitude of each LH pulse was assessed by calculating the area under the curve delineated by the time course of LH above baseline. In eight experiments, a linear regression of these values on volley duration failed to reveal a significant correlation between MUA volley duration and the magnitude of LH pulses. These results suggest that all of the GnRH secreted per pulse is released at the onset of each MUA volley, the remainder of the increase in electrical activity having no further action on GnRH secretion, although effects on other systems cannot be excluded.
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| pubmed:grant | |
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-102738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-2120605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-2125701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-3046375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-3062484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-3317420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-3519645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-3531908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-407069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-462193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-4991672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-6194238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-6378595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-6504270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-6751793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-6751794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-6751801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-7000953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2236069-820547
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0027-8424
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
8580-2
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2236069-Activity Cycles,
pubmed-meshheading:2236069-Animals,
pubmed-meshheading:2236069-Female,
pubmed-meshheading:2236069-Gonadotropin-Releasing Hormone,
pubmed-meshheading:2236069-Hypothalamus,
pubmed-meshheading:2236069-Luteinizing Hormone,
pubmed-meshheading:2236069-Macaca mulatta,
pubmed-meshheading:2236069-Ovariectomy
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Duration of phasic electrical activity of the hypothalamic gonadotropin-releasing hormone pulse generator and dynamics of luteinizing hormone pulses in the rhesus monkey.
|
| pubmed:affiliation |
Laboratory for Neuroendocrinology, University of Texas Medical School, Houston 77225.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|