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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1990-12-7
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pubmed:abstractText |
Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized to six new metabolites in addition to those previously reported (3). Large-scale fermentations with Cunninghamella elegans (ATCC 9245) and Streptomyces lavendulae (L-105) have resulted in the characterization of these metabolites primarily by two-dimensional nuclear magnetic resonance (2D-NMR) methods as 9 beta-hydroxyarteether (2), a ring rearrangement metabolite (3), 3 alpha-hydroxy-11-epi-deoxydihydroartemisinin (4), 9 alpha-hydroxyarteether (5), 2 alpha-hydroxyarteether (6), and 14-hydroxyarteether (7). Thermospray mass spectroscopy/high-performance liquid chromatographic analyses have shown that four of these metabolites (2, 5, 6, 7) are also present in rat liver microsome preparations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0724-8741
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
923-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2235891-Animals,
pubmed-meshheading:2235891-Antimalarials,
pubmed-meshheading:2235891-Artemisinins,
pubmed-meshheading:2235891-Chromatography, High Pressure Liquid,
pubmed-meshheading:2235891-Fermentation,
pubmed-meshheading:2235891-Mass Spectrometry,
pubmed-meshheading:2235891-Microsomes, Liver,
pubmed-meshheading:2235891-Mucorales,
pubmed-meshheading:2235891-Rats,
pubmed-meshheading:2235891-Sesquiterpenes,
pubmed-meshheading:2235891-Streptomyces
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pubmed:year |
1990
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pubmed:articleTitle |
Structure elucidation and thermospray high-performance liquid chromatography/mass spectroscopy (HPLC/MS) of the microbial and mammalian metabolites of the antimalarial arteether.
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pubmed:affiliation |
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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