Linked Life Data

2234509

Source:http://linkedlifedata.com/resource/pubmed/id/2234509

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1990-12-12
pubmed:abstractText
To screen for putative amyloid A4-splitting proteinases, model peptide substrates homologous to the N- and C-terminal portions of the A4 protein were synthesized. The N-terminal A4-splitting enzyme activity was found to be higher in the hypothalamus and limbic area, compared with in the cerebral cortex and cerebellum in 2-month-old rat. The activity decreased throughout the brain in 20-month-old rat. On the other hand, the activity of the putative C-terminal A4-splitting enzyme was significantly higher, 1.4-fold, in the hippocampus than in the cerebral cortex in the young rat. The activity also significantly decreased in the brain of 20-month-old rat, but was still higher in the cerebral cortex, hippocampus and cerebellum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-34
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue.
pubmed:affiliation
National Institute of Neuroscience, NCNP, Tokyo, Japan.
pubmed:publicationType
Journal Article