Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1990-12-12
|
| pubmed:abstractText |
Many neurons possess a proton-activated conductance, IH, which supports a large transient inward current at negative potentials and thereby depolarizes cells during rapid drops in external pH. The channels underlying this conductance are permeant to monovalent cations, with a clear preference for sodium. In earlier experiments, it appeared that divalent cations were impermeant: increasing concentrations of extracellular Ca2+ actually decreased the current amplitude. Using whole-cell patch clamp recording techniques, we find that the proton-activated channel is permeant to Ca2+ ions. In the absence of monovalent cations, a substantial current is supported by divalent cations. The previously reported block results from competition between divalents and monovalents. This finding suggests that IH may provide a pathway for Ca2+ entry during the acidification that accompanies normal synaptic transmission, excessive electrical activity, and tissue ischemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
115
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
237-42
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1990
|
| pubmed:articleTitle |
The proton-activated inward current of rat sensory neurons includes a calcium component.
|
| pubmed:affiliation |
A.A. Bogomoletz Institute of Physiology, Ukrainian Academy of Sciences, Kiev, U.S.S.R.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|