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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4 Pt 2
|
pubmed:dateCreated |
1990-12-5
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pubmed:abstractText |
The safety and effectiveness of oral terbinafine, 125 mg twice daily, and griseofulvin, 250 mg twice daily, in patients with moccasin-type tinea pedis were examined in a double-blind randomized trial. At the end of the 6-week treatment period, both a clinical and mycologic cure or a mycologic cure with minimal signs of infection was noted in 12 (75%) of the 16 terbinafine-treated patients compared with only 3 (27%) of the 12 patients treated with griseofulvin. The overall response rate 2 weeks after the completion of treatment was 88% in the terbinafine-treated group and 45% in the griseofulvin-treated group. When contacted again 6 to 15 months after completion of the study, 94% of the terbinafine-treated patients reported sustained clearing of tinea pedis, and 88% of those with nail involvement at the time of treatment reported improvement. In contrast, tinea pedis remained cured in only 30% of the patients who had received griseofulvin, and onychomycosis improved in only 14%.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Griseofulvin,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/terbinafine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0190-9622
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2229529-Administration, Oral,
pubmed-meshheading:2229529-Adult,
pubmed-meshheading:2229529-Antifungal Agents,
pubmed-meshheading:2229529-Double-Blind Method,
pubmed-meshheading:2229529-Female,
pubmed-meshheading:2229529-Follow-Up Studies,
pubmed-meshheading:2229529-Griseofulvin,
pubmed-meshheading:2229529-Humans,
pubmed-meshheading:2229529-Male,
pubmed-meshheading:2229529-Middle Aged,
pubmed-meshheading:2229529-Naphthalenes,
pubmed-meshheading:2229529-Oxygenases,
pubmed-meshheading:2229529-Remission Induction,
pubmed-meshheading:2229529-Tinea Pedis
|
pubmed:year |
1990
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pubmed:articleTitle |
Oral terbinafine versus griseofulvin in the treatment of moccasin-type tinea pedis.
|
pubmed:affiliation |
Department of Dermatology, Yale University School of Medicine, New Haven, CT.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|