Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-12-27
pubmed:abstractText
Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies (MAbs) to monomorphic framework determinants of HLA sublocus products, beta 2m and Ii, and to CD53, a recently defined broadly distributed pan-leucocyte molecule. Compared with the normal state, an induction/neo-expression of HLA-A,B,C/beta 2m was found in a considerable number of tumors of muscle, peripheral nerve, cartilage-forming, adipose, and vascular tissues. Conversely, some tumors of fibrous origin and of autonomic ganglia showed an abnormal abrogation/loss of HLA-A,B,C/beta 2m with respect to their cells of origin. Small, round tumor cells present in various types of STT exhibited a heterogenous pattern of expression of these molecules with a preponderance of HLA-A, B,C/beta 2m-negativity. HLA-D/Ii determinants were rarely detectable in STT. Besides their expression in some fibrohistiocytic tumors, they were only occasionally found in tumors of smooth-muscle, peripheral-nerve and vascular origin as well as in one clear-cell sarcoma. In all tumors but one, there was no microtopographic association between HLA-D/Ii-positive tumor cells and inflammatory cells. CD53 allowed discrimination between dendritic interstitial cells (DIC) and neoplastic cells and additionally revealed that, in contrast to other solid tumors, STT are generally characterized by an extreme scarcity of lymphohistiocytic infiltrates. Our data indicate that, aside from very rare exceptions, aberrant induction or abrogation of MHC molecules in STT occurs in the absence of lymphohistiocytic stromal infiltrates, suggesting that these alterations might not be a consequence of local cytokine effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
813-23
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed-meshheading:2228310-Adipose Tissue, pubmed-meshheading:2228310-Cartilage, pubmed-meshheading:2228310-Chondrosarcoma, pubmed-meshheading:2228310-Fibroma, pubmed-meshheading:2228310-Fibrosarcoma, pubmed-meshheading:2228310-Ganglia, Autonomic, pubmed-meshheading:2228310-HLA-A Antigens, pubmed-meshheading:2228310-HLA-B Antigens, pubmed-meshheading:2228310-HLA-C Antigens, pubmed-meshheading:2228310-HLA-D Antigens, pubmed-meshheading:2228310-HLA-DP Antigens, pubmed-meshheading:2228310-HLA-DQ Antigens, pubmed-meshheading:2228310-HLA-DR Antigens, pubmed-meshheading:2228310-Humans, pubmed-meshheading:2228310-Liposarcoma, pubmed-meshheading:2228310-Muscle, Smooth, pubmed-meshheading:2228310-Muscle, Smooth, Vascular, pubmed-meshheading:2228310-Muscles, pubmed-meshheading:2228310-Peripheral Nerves, pubmed-meshheading:2228310-Peripheral Nervous System Neoplasms, pubmed-meshheading:2228310-Soft Tissue Neoplasms, pubmed-meshheading:2228310-beta 2-Microglobulin
pubmed:year
1990
pubmed:articleTitle
Expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, -DQ and of HLA-D-associated invariant chain (Ii) in soft-tissue tumors.
pubmed:affiliation
Institute of Pathology, University of Heidelberg, FRG.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't