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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1990-12-4
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pubmed:abstractText |
Insulinlike growth factor I (IGF-I) is the mediator of the growth-promoting effects of growth hormone and has been suspected of playing a role in the pathogenesis of proliferative diabetic retinopathy (PDR). However, previous attempts to correlate IGF-I levels with PDR have yielded conflicting results. We determined IGF-I levels in a large population-based study of 682 early-onset (diagnosed before 30 yr of age) adult (greater than or equal to 18 yr old) insulin-taking diabetic subjects. PDR was found in 25% of the population. IGF-I levels were measured by radioimmunoassay. The mean serum level of IGF-I was 277 +/- 108 micrograms/L (mean +/- SD). Spearman rank correlations showed statistically significant negative correlations between IGF-I levels and age (r = -0.51, P less than 0.0001), duration of disease (r = -0.36, P less than 0.0001), and glycosylated hemoglobin (r = -0.09, P less than 0.05). There was a significant trend (P less than 0.001) toward decreasing risk of PDR with increasing IGF-I. However, after controlling for duration of diabetes, glycosylated hemoglobin, diastolic blood pressure, and the presence of proteinuria and/or creatinine greater than or equal to 265 microM in a multiple logistic regression model, IGF-I was not significantly associated with PDR. These data suggest that IGF-I may not be a risk factor for the development of PDR.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0012-1797
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2227126-Adolescent,
pubmed-meshheading:2227126-Adult,
pubmed-meshheading:2227126-Diabetes Complications,
pubmed-meshheading:2227126-Diabetes Mellitus,
pubmed-meshheading:2227126-Diabetic Retinopathy,
pubmed-meshheading:2227126-Female,
pubmed-meshheading:2227126-Follow-Up Studies,
pubmed-meshheading:2227126-Humans,
pubmed-meshheading:2227126-Insulin-Like Growth Factor I,
pubmed-meshheading:2227126-Male,
pubmed-meshheading:2227126-Middle Aged,
pubmed-meshheading:2227126-Radioimmunoassay,
pubmed-meshheading:2227126-Risk Factors,
pubmed-meshheading:2227126-Wisconsin
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pubmed:year |
1990
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pubmed:articleTitle |
Is insulinlike growth factor I associated with diabetic retinopathy?
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pubmed:affiliation |
Department of Medicine, University of Wisconsin School of Medicine, Madison 53792.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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