| pubmed-article:2223337 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2223337 | lifeskim:mentions | umls-concept:C0025605 | lld:lifeskim |
| pubmed-article:2223337 | lifeskim:mentions | umls-concept:C0683150 | lld:lifeskim |
| pubmed-article:2223337 | lifeskim:mentions | umls-concept:C0002766 | lld:lifeskim |
| pubmed-article:2223337 | lifeskim:mentions | umls-concept:C0032790 | lld:lifeskim |
| pubmed-article:2223337 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2223337 | pubmed:dateCreated | 1990-12-11 | lld:pubmed |
| pubmed-article:2223337 | pubmed:abstractText | Plasma concentrations of methadone were measured by gas chromatography in 16 patients receiving extradural methadone by continuous infusion for relief of postoperative pain. Venous blood samples were taken after a loading dose of extradural methadone 2 mg and during infusion of 0.46 mg h-1 plus patient-controlled increments of 0.2-1 mg. Mean (SD) plasma concentration of methadone was 9.8 (2.1) ng ml-1 at 15 min; this did not change significantly during the first 2 h, after which it increased gradually to 32.2 (4.6) ng ml-1 (P less than 0.001) at the end of 24 h. The mean quantity of extradural methadone required to produce effective analgesia was 10.3 (1.8) mg during the first 12 h after operation and 6 (1.0) mg for the subsequent 12 h. The mean amount of methadone for effective analgesia on the second day was 7.6 (1.1) mg. No adverse effects were detected during the 2-3 days of methadone therapy. Plasma concentration of methadone increased significantly during patient-controlled infusion of extradural methadone in the first 24 h after operation, suggesting rapid vascular uptake. Systemic activity of the drug contributes to the analgesic effect of extradural methadone. | lld:pubmed |
| pubmed-article:2223337 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2223337 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2223337 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2223337 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2223337 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2223337 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2223337 | pubmed:issn | 0007-0912 | lld:pubmed |
| pubmed-article:2223337 | pubmed:author | pubmed-author:MagoraFF | lld:pubmed |
| pubmed-article:2223337 | pubmed:author | pubmed-author:EimerlDD | lld:pubmed |
| pubmed-article:2223337 | pubmed:author | pubmed-author:DalySS | lld:pubmed |
| pubmed-article:2223337 | pubmed:author | pubmed-author:ShihSS | lld:pubmed |
| pubmed-article:2223337 | pubmed:author | pubmed-author:ChrubasikJJ | lld:pubmed |
| pubmed-article:2223337 | pubmed:author | pubmed-author:Schulte-Monti... | lld:pubmed |
| pubmed-article:2223337 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2223337 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:2223337 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2223337 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2223337 | pubmed:pagination | 204-9 | lld:pubmed |
| pubmed-article:2223337 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:meshHeading | pubmed-meshheading:2223337-... | lld:pubmed |
| pubmed-article:2223337 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2223337 | pubmed:articleTitle | Plasma concentrations of methadone during postoperative patient-controlled extradural analgesia. | lld:pubmed |
| pubmed-article:2223337 | pubmed:affiliation | Department of Anaesthesiology, Hadassah University Hospital, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:2223337 | pubmed:publicationType | Journal Article | lld:pubmed |
