Linked Life Data

2222593

Source:http://linkedlifedata.com/resource/pubmed/id/2222593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-12-10
pubmed:abstractText
During general anesthesia, three groups of six patients each received 2 mg/kg lidocaine as a marker substance endobronchially in either 10, 5, or 3 mL distilled water. It was found that the group receiving 10 mL initially exhibited the highest lidocaine plasma concentration with a mean of 2.01 micrograms/mL, in comparison with 1.25 micrograms/mL in the 5 mL group and 0.95 micrograms/mL in the 3 mL group. After about 10 minutes, concentration courses were almost the same in the 10 mL and the 5 mL groups. The PaO2 in the 10 mL group dropped initially by approximately 40 mm Hg on average and remained low over 60 minutes. By this time the PaO2 in the 5 mL group (initial drop 46 mm Hg) had come back to the original value (P less than .05). The 3 mL group exhibited even more favorable courses in the PaO2 (initial drop 16 mm Hg on average). However, the lidocaine plasma concentration was at the lowest at all times in this group and, moreover, under the therapeutic level of 1.5 micrograms/mL with the dosage used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0735-6757
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
504-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
What is the optimal volume of administration for endobronchial drugs?
pubmed:affiliation
Department of Anesthetics, University Hospital, Ulm, FRG.
pubmed:publicationType
Journal Article