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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1979-8-29
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pubmed:abstractText |
The increase of plasma cortisol (F), androstenedione (A), 17 alpha-hydroxy-progesterone (17-OH-P) and testosterone (T) was measured after iv administration of ACTH in heterozygotes for CAH and in controls under two different conditions: Test 1: ACTH stimulation was performed without any particular preparation. Test 2: 1.5 mg of dexamethasone (dex.) was given the evening before the ACTH stimulation. Plasma F, A, 17-OH-P and T were measured by specific radioimmunoassays (RIA). Following ACTH stimulation, the increase of 17-OH-P was significantly higher in CAH-heterozygotes than in controls in both tests (P less than 0.0005). Heterozygotes were characterized by a 17-OH-P increase after ACTH stimulation exceeding the + 2 SD limit of the 17-OH-P increase found in controls. The detection of female heterozygotes was considerably improved by the administration of dex. before testing (test 2). In males, however, a better identification of heterozygotes was obtained without previous administration of dex. (test 1). By these tests, 100% of female (test 2) and 79% of male (test 1) CAH heterozygotes could be correctly identified. There were no significant differences in the levels of F, A and T between heterozygotes and controls except for decreased T levels in test 1 (2P less than 0.01) in most male heterozygotes after ACTH stimulation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Androstenedione,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyprogesterones,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0001-5598
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-21
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:222097-Adrenal Cortex Function Tests,
pubmed-meshheading:222097-Adrenal Hyperplasia, Congenital,
pubmed-meshheading:222097-Adrenocortical Hyperfunction,
pubmed-meshheading:222097-Adrenocorticotropic Hormone,
pubmed-meshheading:222097-Androstenedione,
pubmed-meshheading:222097-Dexamethasone,
pubmed-meshheading:222097-Evaluation Studies as Topic,
pubmed-meshheading:222097-Female,
pubmed-meshheading:222097-Heterozygote,
pubmed-meshheading:222097-Humans,
pubmed-meshheading:222097-Hydrocortisone,
pubmed-meshheading:222097-Hydroxyprogesterones,
pubmed-meshheading:222097-Male,
pubmed-meshheading:222097-Pituitary-Adrenal Function Tests,
pubmed-meshheading:222097-Testosterone
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pubmed:year |
1979
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pubmed:articleTitle |
Comparison of two tests for heterozygosity in congenital adrenal hyperplasia (CAH).
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pubmed:publicationType |
Journal Article,
Comparative Study
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