Linked Life Data

2218071

Source:http://linkedlifedata.com/resource/pubmed/id/2218071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-11-19
pubmed:abstractText
The teratogenicity of nitrazepam, a benzodiazepine-type drug, was investigated in Sprague-Dawley rats. Nitrazepam was administered to pregnant females at levels of 100, 200 or 300 mg/kg in a single dose on one of gestation days 10-14. Fetuses were examined for external and skeletal malformations on day 20 of gestation. Nitrazepam was found to produce various types of malformations, i.e., exencephaly, cleft palate, micrognathia, short or kinky tail and limb reduction defects. The predominant malformation was limb reduction defects, which were produced at high frequency by treatment on day 12 or 13 of gestation. Microscopic examination of limb buds revealed hemorrhage and mesenchymal cell necrosis at 24 hours after nitrazepam treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-70
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Teratogenic effects of nitrazepam in rats.
pubmed:affiliation
Department of Pharmacology, School of Pharmacy, Hokuriku University, Kanazawa, Japan.
pubmed:publicationType
Journal Article