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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1990-11-15
|
| pubmed:abstractText |
[3H]Flunitrazepam (FNZ) binding to cortical neurons from fetal rat brain was investigated in vitro. The use of a synthetic medium specific for neurons made it possible to plot a developmental curve of 3H-FNZ binding in an almost pure neuronal culture. Detectable specific binding was present in vitro at time 0 (that is, the 16th gestational day). A progressive increase of binding, due to an increment in the number of recognition sites, was observed on the subsequent days. The affinity of the specific binding sites to 3H-FNZ was enhanced by the addition of exogenous GABA, whereas the density was not affected.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0364-3190
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
773-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2215857-Animals,
pubmed-meshheading:2215857-Cell Differentiation,
pubmed-meshheading:2215857-Cells, Cultured,
pubmed-meshheading:2215857-Culture Media,
pubmed-meshheading:2215857-Flunitrazepam,
pubmed-meshheading:2215857-Hormones,
pubmed-meshheading:2215857-Neurons,
pubmed-meshheading:2215857-gamma-Aminobutyric Acid
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Binding of flunitrazepam to differentiating neurons cultured in a chemically defined, hormone-supplemented medium.
|
| pubmed:affiliation |
Istituto di Neuropsichiatria, Università degli Studi di Palermo, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|