Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1990-11-16
|
| pubmed:abstractText |
Effects of plasma of the blood under extracorporeal circulation (EC) on erythrocyte shape was determined on 14 patients undergoing open-heart surgery with cardiopulmonary bypass. Reversible echinocytosis was observed under an unfixed condition by mixing washed erythrocytes from normal volunteers with plasma of the patients' blood taken during EC. Either the plasma at the start or at the end of EC had no effect on echinocyte formation, while, the plasma obtained 2-3 hr after the onset of EC induced the most advanced stages of echinocytosis. Only the protein fraction after gel (sephadex G-25) filtration of the plasma induced the echinocytosis. Preheating the plasma at 56 degrees C for 30 min did not destroy the shape-transforming activity of the plasma. The plasma fatty acid/protein ratio was transiently increased with prolongation of EC and the ratio became maximum at 2-3 hr of EC, whereas the plasma cholesterol/protein ratio was kept constant during EC. Fatty acid content of the patients' erythrocytes was also increased accompanying the increase in plasma fatty acid/protein ratio. Therefore, it was suggested that the fatty acid incorporated from the patients' plasma into the cell membrane of the erythrocytes induced the echinocytosis.
|
| pubmed:language |
jpn
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0369-4739
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1152-7
|
| pubmed:dateRevised |
2011-7-27
|
| pubmed:meshHeading | |
| pubmed:year |
1990
|
| pubmed:articleTitle |
[Shape change of erythrocyte induced by plasma during cardiopulmonary bypass for open-heart surgery].
|
| pubmed:affiliation |
Department of Biochemistry, Kyoto Pharmaceutical University, Japan.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|