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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1990-11-14
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pubmed:abstractText |
In Escherichia coli, distinct but similar minicell phenotypes resulting from mutation at the minB locus and increased expression of ftsZ suggested a possible interaction between these genes. A four- to fivefold increase in FtsZ resulting from increased gene dosage was found to suppress the lethality of minCD expressed from the lac promoter. Since increased MinCD did not affect the level of FtsZ, this suggested that MinCD may antagonize FtsZ to inhibit its cell division activity. This possibility was supported by the finding that alleles of ftsZ isolated as resistant to the cell division inhibitor SulA were also resistant to MinCD. Among the ftsZ(Rsa) alleles, two appeared to be completely resistant to MinCD as demonstrated by the lack of an effect of MinCD on cell length and a minicell phenotype observed in the absence of a significant increase in FtsZ. It was shown that SulA inhibits cell division independently of MinCD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-1098854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-16591472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2137246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2145263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2158979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2183414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2645057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2834621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2838458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2994059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2995680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-2996784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-3011743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-3330757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-4597442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-6098521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-6230346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-6327636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-6329742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-6343351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-6991482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2211499-94144
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5610-6
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:2211499-Escherichia coli,
pubmed-meshheading:2211499-Gene Expression Regulation, Bacterial,
pubmed-meshheading:2211499-Genes, Bacterial,
pubmed-meshheading:2211499-Genes, Lethal,
pubmed-meshheading:2211499-Genes, Suppressor,
pubmed-meshheading:2211499-Genotype,
pubmed-meshheading:2211499-Models, Genetic,
pubmed-meshheading:2211499-Mutation,
pubmed-meshheading:2211499-Phenotype,
pubmed-meshheading:2211499-Plasmids
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pubmed:year |
1990
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pubmed:articleTitle |
Interaction between the min locus and ftsZ.
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pubmed:affiliation |
Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City 66103.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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