| pubmed-article:2210999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C0339383 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C0020966 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C0035331 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C1419805 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C2828366 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C1705851 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C1555707 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C0966717 | lld:lifeskim |
| pubmed-article:2210999 | lifeskim:mentions | umls-concept:C2752151 | lld:lifeskim |
| pubmed-article:2210999 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2210999 | pubmed:dateCreated | 1990-11-13 | lld:pubmed |
| pubmed-article:2210999 | pubmed:abstractText | Autoimmune mechanisms are thought to be involved in the pathogenesis of onchocercal chorioretinopathy. Cell-mediated immune responses to human retinal S-antigen, interphotoreceptor retinoid binding protein (IRBP), and crude retinal extract were investigated in patients with onchocerciasis from Sierra Leone, West Africa using a two-step migration-inhibition factor assay. Patients were subdivided into three groups: (1) without ocular involvement (n = 10), (2) with ocular onchocerciasis limited to the anterior segment (n = 19), and (3) with onchocercal chorioretinopathy (n = 21). A group of endemic controls (n = 25) from Sierra Leone were also studied. The cellular immune response to concanavalin A (Con A) was measured to assess the general capacity of lymphocytes to respond to a mitogen. Four of 50 (8%) patients with onchocerciasis and four of 25 (16%) endemic controls reacted with at least one retinal antigen. From the patients with onchocercal chorioretinopathy two of 21 (10%) showed a positive cellular response. The general mitogen response tested with Con A was positive in all these individuals. A role for an antiretinal autoimmune mechanism in the pathogenesis of onchocercal chorioretinopathy, as studied with human S-antigen, IRBP, or crude retinal extract, could not be shown because the cellular response to these antigens did not differ in patients with or without onchocercal chorioretinopathy or in endemic controls. | lld:pubmed |
| pubmed-article:2210999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2210999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2210999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2210999 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2210999 | pubmed:issn | 0146-0404 | lld:pubmed |
| pubmed-article:2210999 | pubmed:author | pubmed-author:KijlstraAA | lld:pubmed |
| pubmed-article:2210999 | pubmed:author | pubmed-author:StilmaJ SJS | lld:pubmed |
| pubmed-article:2210999 | pubmed:author | pubmed-author:RothovaAA | lld:pubmed |
| pubmed-article:2210999 | pubmed:author | pubmed-author:HoekzemaRR | lld:pubmed |
| pubmed-article:2210999 | pubmed:author | pubmed-author:Van der... | lld:pubmed |
| pubmed-article:2210999 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2210999 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:2210999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2210999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2210999 | pubmed:pagination | 2031-6 | lld:pubmed |
| pubmed-article:2210999 | pubmed:dateRevised | 2007-7-27 | lld:pubmed |
| pubmed-article:2210999 | pubmed:meshHeading | pubmed-meshheading:2210999-... | lld:pubmed |
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| pubmed-article:2210999 | pubmed:meshHeading | pubmed-meshheading:2210999-... | lld:pubmed |
| pubmed-article:2210999 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2210999 | pubmed:articleTitle | Cell-mediated immunity against human retinal extract, S-antigen, and interphotoreceptor retinoid binding protein in onchocercal chorioretinopathy. | lld:pubmed |
| pubmed-article:2210999 | pubmed:affiliation | Department of Ophthalmology, Free University, Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:2210999 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2210999 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2210999 | lld:pubmed |
