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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1990-11-13
|
| pubmed:abstractText |
Autoimmune mechanisms are thought to be involved in the pathogenesis of onchocercal chorioretinopathy. Cell-mediated immune responses to human retinal S-antigen, interphotoreceptor retinoid binding protein (IRBP), and crude retinal extract were investigated in patients with onchocerciasis from Sierra Leone, West Africa using a two-step migration-inhibition factor assay. Patients were subdivided into three groups: (1) without ocular involvement (n = 10), (2) with ocular onchocerciasis limited to the anterior segment (n = 19), and (3) with onchocercal chorioretinopathy (n = 21). A group of endemic controls (n = 25) from Sierra Leone were also studied. The cellular immune response to concanavalin A (Con A) was measured to assess the general capacity of lymphocytes to respond to a mitogen. Four of 50 (8%) patients with onchocerciasis and four of 25 (16%) endemic controls reacted with at least one retinal antigen. From the patients with onchocercal chorioretinopathy two of 21 (10%) showed a positive cellular response. The general mitogen response tested with Con A was positive in all these individuals. A role for an antiretinal autoimmune mechanism in the pathogenesis of onchocercal chorioretinopathy, as studied with human S-antigen, IRBP, or crude retinal extract, could not be shown because the cellular response to these antigens did not differ in patients with or without onchocercal chorioretinopathy or in endemic controls.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Arrestin,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Migration-Inhibitory...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinol-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/interstitial retinol-binding protein
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0146-0404
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2031-6
|
| pubmed:dateRevised |
2007-7-27
|
| pubmed:meshHeading |
pubmed-meshheading:2210999-Adolescent,
pubmed-meshheading:2210999-Adult,
pubmed-meshheading:2210999-Aged,
pubmed-meshheading:2210999-Antigens,
pubmed-meshheading:2210999-Arrestin,
pubmed-meshheading:2210999-Child,
pubmed-meshheading:2210999-Choroid Diseases,
pubmed-meshheading:2210999-Eye Proteins,
pubmed-meshheading:2210999-Female,
pubmed-meshheading:2210999-Humans,
pubmed-meshheading:2210999-Immunity, Cellular,
pubmed-meshheading:2210999-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:2210999-Male,
pubmed-meshheading:2210999-Membrane Proteins,
pubmed-meshheading:2210999-Middle Aged,
pubmed-meshheading:2210999-Monocytes,
pubmed-meshheading:2210999-Onchocerciasis, Ocular,
pubmed-meshheading:2210999-Retina,
pubmed-meshheading:2210999-Retinal Diseases,
pubmed-meshheading:2210999-Retinol-Binding Proteins,
pubmed-meshheading:2210999-Tissue Extracts
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Cell-mediated immunity against human retinal extract, S-antigen, and interphotoreceptor retinoid binding protein in onchocercal chorioretinopathy.
|
| pubmed:affiliation |
Department of Ophthalmology, Free University, Utrecht, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|