Linked Life Data

2210446

Source:http://linkedlifedata.com/resource/pubmed/id/2210446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1990-11-1
pubmed:abstractText
We have previously described a 40 kDa colonic protein(s) which is specifically recognised by tissue-bound immunoglobulin G obtained from the colon of patients with ulcerative colitis. We now report the presence of circulating antibodies against this antigen using an enzyme-linked immunosorbent assay with a highly enriched preparation of the 40 kDa protein from normal colon extracts. Serum was collected from 79 patients with ulcerative colitis, 36 with Crohn's disease, 16 with specific diarrhoeal syndromes, and from 19 normal subjects. Twenty nine of 79 patients with ulcerative colitis, 21 of 36 with Crohn's disease, and all patients with diarrhoea were symptomatic during the collection of sera. The difference in optical density values between patients with symptomatic ulcerative colitis and each of the other groups, including patients with ulcerative colitis in remission, was highly significant (p less than 0.01). Seventy nine per cent of patients with symptomatic ulcerative colitis had optical density values above the means for all other groups. Fifty five per cent of sera from patients with symptomatic ulcerative colitis had optical densities beyond two SDs of the values for all other groups and only two of 71 sera from non-ulcerative colitis patients (one Crohn's disease and one normal subject) had values in this range. These results show the presence of anti-colon antibodies against the 40 kDa protein(s) in the sera of many patients with symptomatic ulcerative colitis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-3295053, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-4019782, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-4097744, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-4197968, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-4829119, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-5322083, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-5330184, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-6352104, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-6402708, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-6604226, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-6971876, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-7041258, http://linkedlifedata.com/resource/pubmed/commentcorrection/2210446-7119438
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1016-20
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis.
pubmed:affiliation
Department of Medicine, University of Medicine of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08904.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't