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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1990-11-9
|
| pubmed:abstractText |
This retrospective study examines 105 consecutive infrainguinal bypasses using human umbilical vein (HUV) grafts as blood conduits over a 9 year period. In addition, 39 segments of these grafts were harvested at reoperation and submitted for morphologic, histologic, and scanning electron microscopy examinations. Fifty-two below-knee femoro-popliteal and 53 femoro-distal bypasses were performed in 93 patients. Sixty-seven per cent of these bypasses were performed for either rest pain (18%) or gangrene (49%) and 29% were performed for acute ischemia. Primary and secondary patency rates were not statistically different and were 38% and 29% at 1 and 3 years respectively. Factors found to have a significant effect on patency were site of distal anastomosis, state of distal run-off, and indication for operation. Other complications requiring reoperation included aneurysm formation (8 cases), infection (6 cases), mural thrombus (2 cases), and stenosis (2 cases). Pathologic examination revealed a damaged luminal surface in 22 grafts, deep folds in 8 grafts and delamination of the graft wall in 16 cases. Bacteria were seen in the folds of the grafts and, in addition, the presence of bacteria was documented in 7 out of 26 clinically non-infected grafts. The combination of poor patency rates and pathologic evidence of biodegradative phenomena have led us to discontinue HUV as an arterial substitute.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0147-958X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
155-64
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2208831-Adult,
pubmed-meshheading:2208831-Aged,
pubmed-meshheading:2208831-Aged, 80 and over,
pubmed-meshheading:2208831-Aneurysm,
pubmed-meshheading:2208831-Bacteria,
pubmed-meshheading:2208831-Bacterial Infections,
pubmed-meshheading:2208831-Bioprosthesis,
pubmed-meshheading:2208831-Female,
pubmed-meshheading:2208831-Femoral Artery,
pubmed-meshheading:2208831-Gangrene,
pubmed-meshheading:2208831-Graft Occlusion, Vascular,
pubmed-meshheading:2208831-Humans,
pubmed-meshheading:2208831-Ischemia,
pubmed-meshheading:2208831-Male,
pubmed-meshheading:2208831-Microscopy, Electron, Scanning,
pubmed-meshheading:2208831-Middle Aged,
pubmed-meshheading:2208831-Pain,
pubmed-meshheading:2208831-Reoperation,
pubmed-meshheading:2208831-Retrospective Studies,
pubmed-meshheading:2208831-Umbilical Veins,
pubmed-meshheading:2208831-Vascular Patency
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Human umbilical vein grafts as infrainguinal bypasses: long-term clinical follow-up and pathological investigation of explanted grafts.
|
| pubmed:affiliation |
Service de Chirurgie Vasculaire, Hôpital Annexe-République, C.H.U. de Nice, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|