Linked Life Data

22069531

Source:http://linkedlifedata.com/resource/pubmed/id/22069531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-11-9
pubmed:abstractText
Biosynthesis of the toxic and carcinogenic aflatoxins (AFs) requires the activity of more than 27 enzymes. The roles in biosynthesis of newly described enzymes are discussed in this review. We suggest that HypC catalyzes the oxidation of norsolorinic acid anthrone; AvfA (AflI), the ring-closure step in formation of hydroxyversicolorone; HypB, the second oxidation step in conversion of O-methylsterigmatocystin to AF; and HypE and NorA (AflE), the final two steps in AFB(1) formation. HypD, an integral membrane protein, affects fungal development and lowers AF production while AflJ (AflS), has a partial methyltransferase domain that may be important in its function as a transcriptional co-activator.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Sep
pubmed:issn
2072-6651
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-58
pubmed:dateRevised
2011-11-14
pubmed:year
2009
pubmed:articleTitle
Predicted roles of the uncharacterized clustered genes in aflatoxin biosynthesis.
pubmed:affiliation
Southern Regional Research Center, ARS, USDA/1100 Robert E. Lee Blvd, New Orleans, LA 70124, USA; Email: ken.ehrlich@ars.usda.gov ; Tel.: +1-504-286-4369;
pubmed:publicationType
Journal Article