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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-11-21
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pubmed:abstractText |
1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/- 0.09 (mean +/- s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41-0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non-pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg-1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-2178848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-2772876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-2874974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-3890712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-3988401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-4082138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-6102915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-6439334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-6529528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-6617042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2206788-6669634
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1990
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pubmed:articleTitle |
The excretion of zopiclone into breast milk.
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pubmed:affiliation |
Department of Pharmacotherapeutics, University of Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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