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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-10-23
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pubmed:abstractText |
The three-dimensional structure of a chemotactic protein CheY from Salmonella typhimurium has recently been determined by X-ray crystallography. The structure of this small protein, containing 129 amino acid residues, shows a domain consisting of a central beta-pleated sheet surrounded on both sides by alpha-helices. We have examined the sequence and the arrangement of the structural domains of the CheY protein and have compared them with other nucleotide binding protein sequences and structures. We find that the CheY protein has significant sequence homology to the ras-gene encoded p21 protein. In addition, the structural domains of the two proteins are arranged in a fundamentally similar manner, including the phosphate-binding site (both proteins bind phosphate-containing ligands). The striking similarity in the arrangement of the structural domains of the two proteins suggests that both may serve similar functions as signal transducers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0367-8377
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2205595-Amino Acid Sequence,
pubmed-meshheading:2205595-Bacterial Proteins,
pubmed-meshheading:2205595-Binding Sites,
pubmed-meshheading:2205595-Chemotactic Factors,
pubmed-meshheading:2205595-Membrane Proteins,
pubmed-meshheading:2205595-Molecular Sequence Data,
pubmed-meshheading:2205595-Molecular Structure,
pubmed-meshheading:2205595-Phosphates,
pubmed-meshheading:2205595-Protein Binding,
pubmed-meshheading:2205595-Protein Conformation,
pubmed-meshheading:2205595-Proto-Oncogene Proteins,
pubmed-meshheading:2205595-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:2205595-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2205595-X-Ray Diffraction
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pubmed:year |
1990
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pubmed:articleTitle |
Comparisons between the three-dimensional structures of the chemotactic protein CheY and the normal Gly 12-p21 protein.
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pubmed:affiliation |
Department of Chemistry, New York University, New York.
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pubmed:publicationType |
Journal Article,
Comparative Study
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