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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1990-10-26
|
| pubmed:abstractText |
Exocrine pancreatic marker (immunoreactive-trypsin) and endocrine Beta-cell function (plasma insulin and C-peptide during an oral glucose tolerance test) were studied in 40 subjects with tropical-calcific-pancreatitis [seven non-diabetic, seven with impaired-glucose-tolerance and 26 diabetic (fibro-calculous-pancreatic-diabetes)]. In non-diabetic and impaired-glucose-tolerance subjects there was evidence of active pancreatitis in some and exocrine function was partially preserved. Fibro-calculous-pancreatic-diabetic subjects showed severely diminished exocrine pancreatic function; none showed 'pancreatitic' elevation of immunoreactive-trypsin. Beta-cell function was preserved in non-diabetic and impaired-glucose-tolerance subjects; diabetic subjects showed variable Beta-cell function but it was severely diminished in more than 75%. Immunoreactive-trypsin and C-peptide were directly correlated (rs = 0.55, p less than 0.01). This cross sectional study demonstrates, for the first time, that the Beta-cell loss in tropical-calcific-pancreatitis is related to the exocrine loss. It suggests that diabetes in tropical-calcific-pancreatitis is either secondary to pancreatitis or that a common factor(s) acts simultaneously on both components.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
417-21
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2205529-Adult,
pubmed-meshheading:2205529-Blood Glucose,
pubmed-meshheading:2205529-C-Peptide,
pubmed-meshheading:2205529-Child,
pubmed-meshheading:2205529-Chronic Disease,
pubmed-meshheading:2205529-Diabetes Mellitus,
pubmed-meshheading:2205529-Female,
pubmed-meshheading:2205529-Glucose Tolerance Test,
pubmed-meshheading:2205529-Humans,
pubmed-meshheading:2205529-India,
pubmed-meshheading:2205529-Insulin,
pubmed-meshheading:2205529-Islets of Langerhans,
pubmed-meshheading:2205529-Male,
pubmed-meshheading:2205529-Pancreas,
pubmed-meshheading:2205529-Pancreatitis,
pubmed-meshheading:2205529-Reference Values,
pubmed-meshheading:2205529-Tropical Climate,
pubmed-meshheading:2205529-Trypsin
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
The spectrum of pancreatic exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis.
|
| pubmed:affiliation |
Wellcome Diabetes Study, King Edward Memorial Hospital, Pune, India.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|