| pubmed-article:2203468 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C0346388 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C0021044 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C0085264 | lld:lifeskim |
| pubmed-article:2203468 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:2203468 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2203468 | pubmed:dateCreated | 1990-10-11 | lld:pubmed |
| pubmed-article:2203468 | pubmed:abstractText | Radioimmunoscintigraphy with monoclonal antibodies (MoAbs) to melanoma associated antigens is a new technique that can be used as an additional test to detect ocular melanomas in clinically difficult cases. Immunoscintigraphy with 99mtechnetium-labelled monoclonal antibody fragments of MoAb 225.28S in 14 patients with melanoma yielded a positive image in only six cases (43%). The expression of high molecular weight melanoma-associated antigen (HMW-MAA) was immunohistochemically assessed in melanoma tissue obtained from these 14 patients to find a possible correlation between the results of immunoscintigraphy and expression of the HMW-MAA. The melanoma tissues were immunohistochemically stained by a sensitive immunoperoxidase procedure with three different monoclonal antibodies to the HMW-MAA: 225.28S, Mel-14, and AMF-6. Expression of the antigen detected by MoAb 225.28S was found in 13 of 14 melanomas; the MoAbMel-14 reacted positively with all 14 melanomas; staining with MoAb AMF-6 was achieved in 10 melanomas. No correlation was found between the immunohistochemical staining results, the conventional histopathological findings, and the immunoscintigraphic results. The immunohistochemical staining results suggest that anti-HMW-MAA MoAbs bind to the melanoma tissue and are therefore potentially suitable for immunoscintigraphy. | lld:pubmed |
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| pubmed-article:2203468 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2203468 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2203468 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2203468 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2203468 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2203468 | pubmed:issn | 0007-1161 | lld:pubmed |
| pubmed-article:2203468 | pubmed:author | pubmed-author:OosterhuisJ... | lld:pubmed |
| pubmed-article:2203468 | pubmed:author | pubmed-author:RuiterD JDJ | lld:pubmed |
| pubmed-article:2203468 | pubmed:author | pubmed-author:JagerM JMJ | lld:pubmed |
| pubmed-article:2203468 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:2203468 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:2203468 | pubmed:author | pubmed-author:SchalingD FDF | lld:pubmed |
| pubmed-article:2203468 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2203468 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:2203468 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2203468 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2203468 | pubmed:pagination | 538-41 | lld:pubmed |
| pubmed-article:2203468 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:2203468 | pubmed:meshHeading | pubmed-meshheading:2203468-... | lld:pubmed |
| pubmed-article:2203468 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2203468 | pubmed:articleTitle | Radioimmunoscintigraphy and immunohistochemistry with melanoma-associated monoclonal antibodies in choroidal melanoma: a comparison of the clinical and immunohistochemical results. | lld:pubmed |
| pubmed-article:2203468 | pubmed:affiliation | Department of Ophthalmology, University Hospital, Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:2203468 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2203468 | pubmed:publicationType | Comparative Study | lld:pubmed |
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